Mitomycin-C needle bleb revision in congenital glaucoma

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5.1. Intraoperative use and needling bleb revision with mitomycin C Intraoperative use and needling bleb revision with mitomycin C

MMC when applied topically or injected subconjunctivally, prevents proliferation of fibroblasts within the subconjunctival space and tenon’s capsule. It also has a lethal effect on vascular endothelial cells. A single application of MMC can cause localized, irreversible inhibition of both fibroblasts and vascular endothelial cells. MMC is estimated to be 100 times more potent than 5-FU in fibro...

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needle revision with mitomycin-c in encapsulated blebs

the most common cause of failure during the first trimester after trabeculectomy is encapsulated bleb and needling bleb revision is a less invasive method in the management of refractory cases. the purpose of this study is to determine the efficacy and safety of mitomycin-c (mmc) augmented bleb revision of failed filtration surgery. this study is a before-after (paired) observation. 33 patients...

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Needle Revision with Antimetabolites in Bleb Failure

The signs of bleb failure include sub conjunctival cyst disappearance, increased vascularity, decreasing area of bleb and elevated intraocular pressure (IOP) [6]. Those patients at high risk of bleb failure are Africans, with previous ocular inflammation, prolonged topical medication (miotics and sympathomimetics) and aphakia. As there were a great tendency to subconjunctival, episcleral and sc...

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Needle Revision of Failed Drainage Blebs with Mitomycin-C

.................................. Purpose: To assess the outcome of needle revision of failed drainage blebs with regard to decrease in Intraocular pressure (IOP) of < 20 mmHg over mean follow up of 1 year and to observe the complication associated with the procedure. Material and Methods: This non-comparative, interventional case series of 46 eyes (46 patients) with IOP of > 25 mmHg after tra...

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Postoperative Bleb Management with Topical Mitomycin-C

Despite various developments in many fields of ophthalmology, the surgical therapy of open-angle glaucoma has remained mostly unchanged over the last 30 years. Ever since the introduction of intraoperative mitomycin and postoperative subconjunctival injections of 5-fluorouracil (5-FU), trabeculectomy has not markedly been altered. These facts stand in contrast to the need for a more efficient s...

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ژورنال

عنوان ژورنال: Middle East African Journal of Ophthalmology

سال: 2010

ISSN: 0974-9233

DOI: 10.4103/0974-9233.71598